TargetMol

ERα degrader-2

Product Code:
 
TAR-T39727
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
ERα degrader-2 is a potent selective estrogen receptor degrader (SERD) exhibiting a strong binding affinity to ERα (IC50 = 17.1 nM). It demonstrates efficient degradation efficacy (EC50 = 0.3 nM) and displays favorable pharmacokinetic properties, as well as excellent druggability. ERα degrader-2 represents a promising tool for HER+ breast cancer research.
CAS:
2235396-63-9
Molecular Weight:
492.542
Purity:
0.98
SMILES:
C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(cc1F)-c1ccc(cc1)C(O)=O

References

Xiaomeng Zhang, et al. Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ER?+ Breast Cancer. J Med Chem