TargetMol

Cetirizine Impurity D

Product Code:
 
TAR-T40430
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine is a second-generation antihistamine that acts as a specific, orally active, and long-acting antagonist of the histamine H1-receptor. Cetirizine exhibits antiallergic properties and inhibits eosinophil chemotaxis in response to allergies.
CAS:
346451-15-8
Molecular Weight:
487.46
Purity:
0.98
SMILES:
ClC1=CC=C(C=C1)C(C=2C=CC=CC2)N3CCN(CC3)C(C=4C=CC=CC4)C5=CC=C(Cl)C=C5

References

Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993.