TargetMol

Solnatide

Product Code:
 
TAR-TP2408
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TP2408-500mg500mgEnquire
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  • Further Information
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Further Information

Bioactivity:
Solnatide is a synthetic peptide mimicking the lectin-like domain of TNF.
CAS:
259206-53-6
Molecular Weight:
1923.09
Purity:
0.98
SMILES:
C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@]4(N(C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@]5(N(C(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC[C@@H](C(O)=O)NC(=O)[C@H](CC6=CC=C(O)C=C6)NC3=O)[H])CCC5)[H])CCC4)[H]

References

Willam A, Aufy M, Tzotzos S, El-Malazi D, Poser F, Wagner A, Unterk?fler B, Gurmani D, Martan D, Iqbal SM, Fischer B, Fischer H, Pietschmann H, Czikora I, Lucas R, Lemmens-Gruber R, Shabbir W. TNF Lectin-Like Domain Restores Epithelial Sodium Channel Function in Frameshift Mutants Associated with Pseudohypoaldosteronism Type 1B. Front Immunol. 2017 May 29;8:601. doi: 10.3389/fimmu.2017.00601. eCollection 2017. PubMed PMID: 28611771; PubMed Central PMCID: PMC5447021. Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I. The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the ?-Subunit. J Biol Chem. 2016 Nov 4;291(45):23440-23451. Epub 2016 Sep 19. PubMed PMID: 27645999; PubMed Central PMCID: PMC5095400. van den Berg E, Bem RA, Bos AP, Lutter R, van Woensel JB. The effect of TIP on pneumovirus-induced pulmonary edema in mice. PLoS One. 2014 Jul 21;9(7):e102749. doi: 10.1371/journal.pone.0102749. eCollection 2014. PubMed PMID: 25047452; PubMed Central PMCID: PMC4105480. Shabbir W, Tzotzos S, Bedak M, Aufy M, Willam A, Kraihammer M, Holzner A, Czikora I, Scherbaum-Hazemi P, Fischer H, Pietschmann H, Fischer B, Lucas R, Lemmens-Gruber R. Glycosylation-dependent activation of epithelial sodium channel by solnatide. Biochem Pharmacol. 2015 Dec 15;98(4):740-53. doi: 10.1016/j.bcp.2015.08.003. Epub 2015 Aug 5. PubMed PMID: 26254591.