AdipoGen Life Sciences

W-5 . hydrochloride

Product Code:
 
AG-CR1-0003
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
1 / 1
Chemical Structure
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Chemical Structure

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AG-CR1-0003-M0055 mg£50.00
Quantity:
AG-CR1-0003-M02525 mg£105.00
Quantity:
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Further Information

Alternate Names/Synonyms:
N-(6-Aminohexyl)-1-naphthalenesulfonamide . HCl
Appearance:
White to off-white crystalline solid.
CAS:
61714-25-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Hygroscopic.Protect from light.
InChi:
InChI=1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChiKey:
HOCSVIGHWPLMFC-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 61714-25-8. Formula: C16H22N2O2S . HCl. MW: 306.4 . 36.5. Calmodulin antagonist. Cell proliferation inhibitor. Ca2+/calmodulin-regulated phosphodiesterase (PDE I) inhibitor. Myosin light chain kinase (MLCK) inhibitor.
MDL:
MFCD00058043
Molecular Formula:
C16H22N2O2S . HCl
Molecular Weight:
306.4 . 36.5
Package Type:
Vial
Product Description:
Calmodulin antagonist [1-3]. Cell proliferation inhibitor [1]. Ca2+/calmodulin-regulated phosphodiesterase (PDE I) inhibitor [3]. Myosin light chain kinase (MLCK) inhibitor [4].
Purity:
>98% (NMR)
SMILES:
[Cl-].[NH3+]CCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1
Solubility Chemicals:
Soluble in DMSO or 100% ethanol (slightly soluble).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) | W-5 and quin 2-AM reverse the inhibitory effect of insulin on lipolysis due to dibutyryl cAMP: H. Goko & A. Matsuoka; Diabetes Res. Clin. Pract. 44, 101 (1999) | Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells: A. Gulino, et al.; Cancer Res. 46, 6274 (1986) | Hydrophobic regions function in calmodulin-enzyme(s) interactions.: T. Tanaka & H. Hidaka ; J. Biol. Chem. 255, 11078 (1980)