AdipoGen Life Sciences

Necrostatin-5

Product Code:
 
AG-CR1-0049
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
+4°C
Storage:
 
4°C
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Chemical Structure
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Chemical Structure

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AG-CR1-0049-M0055 mg£45.00
Quantity:
AG-CR1-0049-M02525 mg£150.00
Quantity:
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This product comes from: Switzerland.
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  • Further Information
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Further Information

Alternate Names/Synonyms:
Nec-5; 3-p-Methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
Appearance:
White to off-white solid.
CAS:
337349-54-9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H319, H413
InChi:
InChI=1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChiKey:
VGONMECBFMCKBS-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 337349-54-9. Formula: C19H17N3O2S2. MW: 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective
MDL:
MFCD01448275
Molecular Formula:
C19H17N3O2S2
Molecular Weight:
383.5
Package Type:
Vial
Precautions:
P273, P280, P305, P351, P338, P337, P313
Product Description:
Necroptosis inhibitor [1]. Indirect RIP1 kinase inhibitor [2]. Cardioprotective
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
COC1=CC=C(C=C1)N1C(=O)C2=C(SC3=C2CCCC3)N=C1SCC#N
Solubility Chemicals:
Soluble in DMSO (> 10 mg/ml).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5: K. Wang, et al.; Bioorg. Med. Chem. Lett. 17, 1455 (2007) | Idenfication of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008) | Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion: Y.V. Dimitriev, et al.; Bull. Exp. Biol. Med. 155, 245 (2013)