AdipoGen Life Sciences

BIX 01294

Product Code:
 
AG-CR1-0051
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CR1-0051-M0011 mg£40.00
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AG-CR1-0051-M0055 mg£70.00
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AG-CR1-0051-M02525 mg£250.00
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Further Information

Alternate Names/Synonyms:
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine
Appearance:
White to off-white solid.
CAS:
935693-62-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
InChiKey:
OSXFATOLZGZLSK-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 935693-62-2. Formula: C28H38N6O2. MW: 490.6. Selective and cell permeable G9a histone-lysine methyltransferase (HMTase) inhibitor. Does not compete with cofactor S-adenosylmethionine. Pluripotent stem cell inducer.
MDL:
MFCD14560563
Molecular Formula:
C28H38N6O2
Molecular Weight:
490.6
Package Type:
Vial
Product Description:
Selective and cell permeable G9a [Euchromatic Histone-lysine MethylTransferases EHMT2] histone-lysine methyltransferase (HMTase) inhibitor [1]. Does not compete with cofactor S-adenosylmethionine [1]. Pluripotent stem cell inducer [2, 3].
Purity:
>98% (NMR, HPLC)
SMILES:
[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC
Solubility Chemicals:
Soluble in DMSO (5 mg/ml), 100% ethanol or dimethyl formamide.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase: S. Kubicek, et al.; Mol. Cell 25, 473 (2007) | Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds: Y. Shi, et al.; Cell Stem Cell 3, 568 (2008) | Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach: J.R. Plews, et al.; PLoS One 5, e14397 (2010) | Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma: J. A. Seier, et al.; J. Immunother. Cancer 9, e001335 (2021)