Further Information
Alternate Names/Synonyms:
Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
Shows the biological function of the LTbetaR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
32160000
<0.06EU/µg protein (LAL test; Lonza).
solid
Lyophilized from 0.2µm-filtered solution in PBS.
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Protein. The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >98% (SDS-PAGE). The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
NP_002333.1
Plastic Vial
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
>98% (SDS-PAGE)
The extracellular domain of human LTbetaR (aa 31-225) is fused to the N-terminus of the Fc region of a mutant human IgG1.
CHO cells
Fc
Non-hazardous
Other Proteins
12352202
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.