Semaphorin-4A (mouse):Fc (human) (rec.)
Product Code:
CHI-MF-111SEMA4
CHI-MF-111SEMA4
Host Type:
Hamster
Hamster
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Shipping:
BI
BI
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CHI-MF-111SEMA4-C100 | 100 ug | £455.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
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Further Information
Alternate Names/Synonyms:
Sema4a; Semaphorin-B; Sema B
EClass:
32160000
Endotoxin:
<0.06EU/µg protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. The extracellular domain of mouse Semaphorin-4A (aa 1-676) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >98% (SDS-PAGE). Semaphorin 4A (Sema4A, previously semB) is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. Sema4A was first described as a molecule that enhances T cell activation and interacts with TIM2 (T cell immunoglobulin and mucin domain 2). Mice with targeted disruption of Sema4A show defects in dendritic cellmediated T cell priming and Th1 responses. Roles for Sema4A have also been identified in the brain, the endothelium and the eye. It mediates hippocampal neuron growth cone collapse in vitro through interaction of the sema domain with plexinB1. Interaction of Sema4A with endothelial cell plexinD1 causes opposition to the angiogenic, proliferative, chemotactic and integrin mediated adhesive actions of VEGF.
NCBI, Uniprot Number:
NP_038686.3
Package Type:
Plastic Vial
Product Description:
Semaphorin 4A (Sema4A, previously semB) is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. Sema4A was first described as a molecule that enhances T cell activation and interacts with TIM2 (T cell immunoglobulin and mucin domain 2). Mice with targeted disruption of Sema4A show defects in dendritic cellmediated T cell priming and Th1 responses. Roles for Sema4A have also been identified in the brain, the endothelium and the eye. It mediates hippocampal neuron growth cone collapse in vitro through interaction of the sema domain with plexinB1. Interaction of Sema4A with endothelial cell plexinD1 causes opposition to the angiogenic, proliferative, chemotactic and integrin mediated adhesive actions of VEGF.
Purity:
>95% (SDS-PAGE)
Sequence:
The extracellular domain of mouse Semaphorin-4A (aa 1-676) is fused to the N-terminus of the Fc region of human IgG1.
Source / Host:
CHO cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.