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anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2)

Product Code:
 
JAI-MHN-100P
Product Group:
 
Primary Antibodies
Supplier:
 
JaICA
Antibody Isotype:
 
Mouse IgG1kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
HNEJ-2
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
BLUE ICE
Storage:
 
-20°C
1 / 1
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JAI-MHN-100P-100ug100 ug£658.00
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Further Information

EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized. Contains 50mM Tris-buffered saline (TBS).
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
4-Hydroxy-2-nonenal (4-HNE) modified keyhole limpet hemocyanin.
Long Description:
Monoclonal Antibody. Recognizes 4-HNE-lysine, 4-HNE-histidine and 4-HNE cysteine adduct. Has much higher affinity for the 4-HNE-histidine adduct than 4-HNE-lysine or 4-HNE cysteine adduct. Shows almost negligible reactivity with proteins that were treated with other aldehydes, such as 2-nonenal, 2-hexenal, 1-hexanal, 4-hydroxy-2-hexenal, formaldehyde, or glutaraldehyde. Lyophilized. Contains 50mM Tris-buffered saline (TBS). Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.
Package Type:
Plastic Vial
Product Description:
Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.
Source / Host:
Ascites
Specificity:
Recognizes 4-HNE-lysine, 4-HNE-histidine and 4-HNE cysteine adduct. Has much higher affinity for the 4-HNE-histidine adduct than 4-HNE-lysine or 4-HNE cysteine adduct. Shows almost negligible reactivity with proteins that were treated with other aldehydes, such as 2-nonenal, 2-hexenal, 1-hexanal, 4-hydroxy-2-hexenal, formaldehyde, or glutaraldehyde.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C.

References

The monclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct: S.Toyokuni, et al.; FEBS Lett. 359, 189 (1995) [Western blot] | Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion: T. Tanaka, et al.; Lab. Invest. 77, 145 (1997) | Click here for more literature references! http://www.jaica.com/e/technical_forum.html#4HNE_AB_REF