AdipoGen Life Sciences

CREB-binding Protein (mouse) (rec.) (His) (highly active)

Product Code:
 
AG-40T-0016
Product Group:
 
Recombinant Proteins
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Shipping:
 
Dry Ice
Storage:
 
-20°C
 

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AG-40T-0016-C0022 ug£207.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
CBP; CREBBP
Biological Activity:
~50-100ng are required for standard HAT assay.
Concentration:
Lot dependent (0.2-0.5mg/ml)
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
Handling Advice:
After opening, prepare aliquots and store at -80°C.Avoid freeze/thaw cycles.
Long Description:
Protein. Mouse full-length CREB-binding protein fused at the C-terminus to a His-tag. Source: Sf21 cells. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol. Purity: >95% (SDS-PAGE). CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
NCBI, Uniprot Number:
P45481
Package Type:
Plastic Vial
Product Description:
CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
Purity:
>95% (SDS-PAGE)
Sequence:
Mouse full-length CREB-binding protein fused at the C-terminus to a His-tag.
Source / Host:
Sf21 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -80°C.

References

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65: C. Buerki, et al.; Nucleic Acids Res. 36, 1665 (2008)