Further Information
GSTP1 Antibody: PI, DFN7, GST3, GSTP, FAEES3, HEL-S-22, Glutathione S-transferase P, GST class-pi
GSTP1 antibody can be used for the detection of ATG10 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
GSTP1 Antibody: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism (i.e., the metabolism of environmental mutagens and carcinogens) and may play a role in susceptibility to cancer. More recent experiments have suggested that differential expression of GSTP1 also contributes to the sensitivity of xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders such as Parkinson's disease. CpG island hypermethylation of the GSTP1 promoter leading to the silencing of the GSTP1 gene has also been linked to cancer.
- Pearson WR. Phylogenies of glutathione transferase families. Methods Enzymol.2005; 401:186-204.
- Clapper ML. Genetic polymorphism and cancer risk. Curr. Oncol. Rep.2000; 2:251-6.
- Smeyne M, Boyd J, Shepherd KR, etc. GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Proc. Natl. Acad. Sci. USA2007; 104:1977-82.
- Ellinger J, Bastian PJ, Jurgan T, et al. CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. Urology2008; 71:161-7.
GSTP1 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine: (93%), Goat: (86%), Pig: (85%)
GSTP1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human GSTP1.
The immunogen is located within amino acids 90 - 140 of GSTP1.
2950
glutathione S-transferase pi 1
GSTP1
Homo sapiens
Liquid
NP_000843
4504183
GSTP1 Antibody is affinity chromatography purified via peptide column.
Homeostasis
P09211
Optimal dilutions for each application to be determined by the researcher.