ProSci

FXYD7 Antibody

Product Code:
 
PSI-6465
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of FXYD7 in human lung tissue lysate with FXYD7 antibody at 1 μg/mL.
2 / 3
Immunohistochemistry of FXYD7 in rat lung tissue with FXYD7 antibody at 2.5 μg/mL.
3 / 3
Immunofluorescence of FXYD4 in rat lung tissue with FXYD4 antibody at 20 μg/mL.
❮❯

Western blot analysis of FXYD7 in human lung tissue lysate with FXYD7 antibody at 1 μg/mL.
Immunohistochemistry of FXYD7 in rat lung tissue with FXYD7 antibody at 2.5 μg/mL.
Immunofluorescence of FXYD4 in rat lung tissue with FXYD4 antibody at 20 μg/mL.

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CodeSizePrice
PSI-6465-0.02mg0.02mg£150.00
Quantity:
PSI-6465-0.1mg0.1mg£449.00
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Further Information

Additional Names:
FXYD7 Antibody: FXYD domain-containing ion transport regulator 7
Application Note:
FXYD7 antibody can be used for detection of FXYD7 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
FXYD7 Antibody: FXYD7 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing seven invariant and six highly conserved amino acids. The FXYD proteins are tissue-specific regulators of Na, K-ATPase, with FXYD7 initially identified as a brain-specific member. FXYD7 interacts with Na, K-ATPase through its transmembrane domain and is thought to influence the affinity of Na, K-ATPase for external K+ and Na+ ions. Other members of the FXDY family have similar functions: FXYD2 regulates the properties of Na, K-ATPase, while FXYD1 (phospholemman), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems.
Background References:
  • Beguin P, Crambert G, Monnet-Tschudi F, et al. FXYD7 is a brain-specific regulator of Na,K-ATPase alpha1-beta isozymes. EMBO J. 2002; 21:3264-73
  • Crambert G and Geering K. FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase. Sci. STKE 2003; 2003 (166):RE1.
  • Li C, Crambert G, Thuillard D, et al. role of the transmembrane domain of FXDY7 in structural and functional interactions with Na,K-ATPase. J. Biol. Chem. 2005; 280:42738-43.
Buffer:
FXYD7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (71%)
Immunogen:
FXYD7 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human FXYD7.

The immunogen is located within the first 50 amino acids of FXYD7.
NCBI Gene ID #:
53822
NCBI Official Name:
FXYD domain containing ion transport regulator 7
NCBI Official Symbol:
FXYD7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAH18619
Protein GI Number:
11612659
Purification:
FXYD7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
FXYD7 antibody is human, mouse and rat reactive. FXYDY7 antibody is predicted to not react with other members of the FXDY protein family
Swissprot #:
P58549
User NOte:
Optimal dilutions for each application to be determined by the researcher.