ProSci

ECRG1 Antibody

Product Code:
 
PSI-6521
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Chicken
Antibody Isotype:
 
IgY
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of ECRG1 in mouse liver tissue lysate with ECRG1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Western blot analysis of ECRG1 in mouse liver tissue lysate with ECRG1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

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CodeSizePrice
PSI-6521-0.02mg0.02mg£150.00
Quantity:
PSI-6521-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
ECRG1 Antibody: ECRG1, ECRG1, HATL1, HESP, Transmembrane protease serine 11A, Airway trypsin-like protease 1
Application Note:
ECRG1 antibody can be used for detection of ECRG1 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
ECRG1 Antibody: Epidermal type-II transmembrane serine protease (ECRG1), also known as TMPRSS11A, is a member of a novel esophageal cancer-related gene family. It is a type-II transmembrane serine protease which may play a role in cellular senescence. It is expressed in esophagus, liver, colon and lung. Overexpression of ECRG1 inhibits cell growth and induces G1 cell cycle arrest. It is down-regulated in esophagus cancers (EC) and might play important roles in the initiation and progression of EC.
Background References:
  • Yueying W, Jianbo W, Hailin L, et al. ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors. Carcinogenesis 2008; 29:157-60.
  • Zhao N, Wang J, Cui Y, et al. Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1. J. Cell Biochem. 2004; 92:65-76
  • Zhao N, Huang G, Guo L, et al. ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. Exp. Biol. Med. 2006; 231:84-90.
Buffer:
ECRG1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ECRG1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG1.

The immunogen is located within amino acids 300 - 350 of ECRG1.
NCBI Gene ID #:
339967
NCBI Official Name:
transmembrane protease, serine 11A
NCBI Official Symbol:
TMPRSS11A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q6ZMR5
Protein GI Number:
167466250
Purification:
ECRG1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
At least two isoforms of ECRG1 are known to exist; ECRG1 antibody is predicted to not cross-react with other ECRG family members.
Swissprot #:
Q6ZMR5
User NOte:
Optimal dilutions for each application to be determined by the researcher.