ProSci

SIGLEC15 Antibody

Product Code:
 
PSI-6765
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 2
Western blot analysis of SIGLEC15 in human kidney tissue lysate with SIGLEC15 antibody at (A) 1 and (B) 2 μg/mL.
2 / 2
Immunohistochemistry of SIGLEC15 in human kidney tissue with SIGLEC15 antibody at 2.5 μg/mL.
❮❯

Western blot analysis of SIGLEC15 in human kidney tissue lysate with SIGLEC15 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of SIGLEC15 in human kidney tissue with SIGLEC15 antibody at 2.5 μg/mL.

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CodeSizePrice
PSI-6765-0.02mg0.02mg£150.00
Quantity:
PSI-6765-0.1mg0.1mg£449.00
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Further Information

Additional Names:
SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15
Application Note:
SIGLEC15 antibody can be used for detection of SIGLEC15 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
Background References:
  • Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.
  • Angata et al. Glycobiology 2007; 17:838-46.
  • Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.
Buffer:
SIGLEC15 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SIGLEC15 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SIGLEC15.

The immunogen is located within amino acids 50 - 100 of SIGLEC15.
NCBI Gene ID #:
284266
NCBI Official Name:
sialic acid binding Ig-like lectin 15
NCBI Official Symbol:
SIGLEC15
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 36 kDa

Observed: 42 kDa
Protein Accession #:
NP_998767
Protein GI Number:
47106069
Purification:
SIGLEC15 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
SIGLEC15 antibody is predicted to not cross-react with other SIGLEC family members.
Swissprot #:
Q6ZMC9
User NOte:
Optimal dilutions for each application to be determined by the researcher.