ProSci

BMP15 Antibody

Product Code:
 
PSI-6909
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of BMP15 in human testis tissue lysate with BMP15 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunocytochemistry of BMP15 in 3T3 cells with BMP15 antibody at 2.5 μg/mL.
3 / 3
Immunofluorescence of BMP15 in 3T3 cells with BMP15 antibody at 20 μg/mL.
❮❯

Western blot analysis of BMP15 in human testis tissue lysate with BMP15 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of BMP15 in 3T3 cells with BMP15 antibody at 2.5 μg/mL.
Immunofluorescence of BMP15 in 3T3 cells with BMP15 antibody at 20 μg/mL.

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CodeSizePrice
PSI-6909-0.02mg0.02mg£150.00
Quantity:
PSI-6909-0.1mg0.1mg£449.00
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Further Information

Additional Names:
BMP15 Antibody: ODG2, POF4, GDF9B, Bone morphogenetic protein 15, BMP-15
Application Note:
BMP15 antibody can be used for detection of BMP15 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
BMP15 Antibody: BMP15, or GDF9B is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily that are involved in embryonic development and adult tissue homeostasis. BMP15 is expressed exclusively in the oocyte. It is an oocyte-specific growth/differentiation factor that may be involved in oocyte maturation and follicular development. Defects in BMP15 are the cause of ovarian dysgenesis type 2. BMP15 could be used as an oogenesis marker to track human amniotic fluid stem cells differentiation into the oocyte-like cells.
Background References:
  • Massagu? J. The transforming growth factor-beta family. Ann. Rev. Cell. Biol. 1990; 6:597-641
  • Aaltonen J, Laitinen MP, Vuojolainen K, et al. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early foliculogenesis. J. Clin. Endocrinol. Metab. 1999; 84:2744-50.
  • Laitinen M, Vuojolainen K, Jaatinen R, et al. A novel growth differentiation factor-9 (GDF-9) related factor is coexpressed with GDF-9 in mouse oocytes during folliculogenesis. Mech. Dev. 1998; 78:135-40.
  • Galloway SM, Gregan SM, Wilson T et al. Bmp15 mutations and ovarian function. Mol. Cell Endocrinol. 2002; 191:15-8.
Buffer:
BMP15 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (75%), Sheep: (75%)
Immunogen:
BMP15 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human BMP15.

The immunogen is located within amino acids 30 - 80 of BMP15.
NCBI Gene ID #:
9210
NCBI Official Name:
bone morphogenetic protein 15
NCBI Official Symbol:
BMP15
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 45 kDa

Observed: 50 kDa
Protein Accession #:
NP_005439
Protein GI Number:
257743454
Purification:
BMP15 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
It is closely related to GDF9.
Swissprot #:
O95972
User NOte:
Optimal dilutions for each application to be determined by the researcher.