ProSci

KCNJ1 Antibody

Product Code:
 
PSI-25-261
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
For short periods of storage (days) store at 4˚C. For longer periods of storage, store KCNJ1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
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Antibody used in WB on Mouse renal epithelial at: 1:500 (Lane 1: 30ug mouse renal epithelial lysate, Lane 2: 30ug mouse renal epithelial lysate, Lane 3: 30ug mouse renal epithelial lysate).
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Antibody used in WB on Mouse renal epithelial at: 1:500 (Lane 1: 30ug mouse renal epithelial lysate, Lane 2: 30ug mouse renal epithelial lysate, Lane 3: 30ug mouse renal epithelial lysate).

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PSI-25-261-100ul100ul£662.00
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Further Information

Additional Names:
KCNJ1, KIR1.1, ROMK, ROMK1
Application Note:
KCNJ1 antibody can be used for detection of KCNJ1 by ELISA at 1:312500. KCNJ1 antibody can be used for detection of KCNJ1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Background:
KCNJ1 has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for KCNJ1.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Background References:
  • Tobin, M.D., (2008) Hypertension 51 (6), 1658-1664.
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNJ1.
NCBI Gene ID #:
3758
NCBI Official Name:
potassium inwardly-rectifying channel, subfamily J, member 1
NCBI Official Symbol:
KCNJ1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
NP_000211
Protein GI Number:
4504837
Purification:
Antibody is purified by peptide affinity chromatography method.
Research Area:
Membrane
Swissprot #:
P48048
User NOte:
Optimal dilutions for each application to be determined by the researcher.