ProSci

IL-10 Monoclonal Antibody

Product Code:
 
PSI-32-227
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1.kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3C12C12
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
to IL-10 monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis using IL - 10 monoclonal antibody against truncated IL - 10 recombinant protein.
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Western blot analysis using IL - 10 monoclonal antibody against truncated IL - 10 recombinant protein.

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PSI-32-227-0.1mg0.1mg£452.00
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Further Information

Additional Names:
Cytokine synthesis inhibitory factor, IL-10, CSIF, TGIF, GVHDS, IL10A
Application Note:
Western Blot:1:500 - 1,000
ELISA:Determining optimal working dilutions by titration test.
Background:
Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Background References:
  • Vieira P, et al. PNAS, 1991.88:1172-1176.
Buffer:
Purified antibody in PBS containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified recombinant human IL-10 expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
3586
NCBI Official Name:
interleukin 10
NCBI Official Symbol:
IL10
NCBI Organism:
Homo sapiens
Protein Accession #:
P22301
Protein GI Number:
124292
Purification:
Antibody is purified by protein A affinity chromatography.
Research Area:
Immunology ,Innate Immunity
Swissprot #:
P22301
User NOte:
Optimal dilutions for each application to be determined by the researcher.