ProSci

BLK Monoclonal Antibody

Product Code:
 
PSI-32-118
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
9D10B7H6
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
BLK monoclonal antibody can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis using BLK monoclonal antibody against truncated BLK recombinant protein.
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Western blot analysis using BLK monoclonal antibody against truncated BLK recombinant protein.

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PSI-32-118-0.1mL0.1mL£524.00
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
B lymphocyte kinaseMODY11
Application Note:
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Background:
BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
Background References:
  • Theresa Tretter, Ashley E. Ross, Dominic I. Dordai. J. Exp. Med., Dec 2003; 198: 1863.
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ni-NTA purified truncated recombinant BLK expressed in E. Coli strain BL21 (DE3).
NCBI Gene ID #:
640
NCBI Official Name:
B lymphoid tyrosine kinase
NCBI Official Symbol:
BLK
NCBI Organism:
Homo sapiens
Protein Accession #:
P51451
Protein GI Number:
158936749
Research Area:
Apoptosis
Swissprot #:
P51451
User NOte:
Optimal dilutions for each application to be determined by the researcher.