Chemodex

N-tert-Butyl-alpha-phenylnitrone [PBN]

Product Code:
 
CDX-B0269
Product Group:
 
Inhibitors and Activators
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
AMBIENT
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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CDX-B0269-G0011 g£65.00
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CDX-B0269-G0055 g£230.00
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Further Information

Alternate Names/Synonyms:
Phenyl N-t-butylnitrone; N-tert-Butyl-alpha-phenylnitrone; N-Benzylidene-N-(2-methyl-2-propanyl)amine oxide; (Z)-N-Benzylidene-2-methylpropan-2-amine oxide
Appearance:
Off-white to white crystals.
CAS:
3376-24-7
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
InChi:
InChI=1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3
InChiKey:
IYSYLWYGCWTJSG-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 3376-24-7. Formula: C11H15NO. MW: 177.2. Synthetic. Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-kappaB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase (iNOS). Shows anti-cancer activity in several experimental cancer models.
MDL:
MFCD00008799
Molecular Formula:
C11H15NO
Molecular Weight:
177.2
Package Type:
Vial
Product Description:
Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-kappaB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase (iNOS). Shows anti-cancer activity in several experimental cancer models.
Purity:
>98% (GC)
SMILES:
CC(C)(C)[N+]([O-])=CC1=CC=CC=C1
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Spin Labels
UNSPSC Number:
12352100
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) R.A. Floyd; FASEB J. 4, 2587-4597 (1990) | (2) R.F. Haseloff; FEBS Lett. 418, 73 (1997) | (3) R.A. Floyd; Adv. Pharmacol. 38, 361 (1997) | (4) T. Miyajima & Y. Kotake; Free Radic. Biol. Med. 22, 463 (1997) | (5) Y. Kotake, et al.; Biochim. Biophys. Acta 1448, 77 (1998) | (6) R.A. Floyd; Proc. Soc. Exp. Biol. Med. 222, 236 (1999) (Review) | (7) Y. Kotake; Antioxid. Redox Signal. 1, 481 (1999) (Review) | (8) E. Ho, et al.; Free Radic. Biol. Med. 28, 604 (2000) | (9) P. Kelicen, et al.; Neuroreport 13, 1057 (2002) | (10) W.N. Hassan, et al.; Free Radic. Biol. Med. 32, 551 (2002) | (11) K. Saito & H. Yoshioka; Free Radic. Res. 36, 143 (2002) | (12) R.A Floyd; Anticanc. Agents Med. Chem. 11, 373 (2011)