AdipoGen Life Sciences

Suc-Leu-Leu-Val-Tyr-AMC

Product Code:
 
AG-CP3-0016
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
-20°C
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Chemical Structure
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Chemical Structure

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AG-CP3-0016-M0011 mg£35.00
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AG-CP3-0016-M0055 mg£75.00
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Further Information

Alternate Names/Synonyms:
Suc-LLVY-AMC; Proteasome Substrate; Calpain Substrate, Cathepsin B Substrate
Appearance:
Solid lyophilized powder.
CAS:
94367-21-2
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Avoid freeze/thaw cycles.Protect from light.
InChi:
InChI=1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)/t29-,30-,31-,36-/m1/s1
InChiKey:
UVFAEQZFLBGVRM-FEIGSSFXSA-N
Long Description:
Chemical. CAS: 94367-21-2. Formula: C40H53N5O10. MW: 763.9. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction: 380nm. Emission: 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
MDL:
MFCD00080248
Molecular Formula:
C40H53N5O10
Molecular Weight:
763.9
Other data:
Use: Add from DMSO stock directly to in vitro or in vivo assays at desired concentration. Typical concentrations range from 10-100µM.
Package Type:
Vial
Product Description:
Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction: 380nm. Emission: 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
Purity:
>95% (HPLC)
Sequence:
N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin
SMILES:
CC(C)C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NC1=CC2=C(C=C1)C(C)=CC(=O)O2
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates: T. Sasaki, et al.; J. Biol. Chem. 259, 12489 (1984) | Kinetic characterization of the chymotryptic activity of the 20S proteasome: R.L. Stein, et al.; Biochemistry 35, 3899 (1996) | 26S proteasome activity is down-regulated in lung cancer stem-like cells propagated in vitro: J. Pan, et al.; PLoS One 5, e13298 (2010) | Low cell density induced epithelial-mesenchymal transition in MCF10A cell is regulated by proteasome activity: J. Fu, et al.; J. Oncobiomark. 1, 4 (2013) | Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013) | Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation: J. Moore, et al.; Cells 10, 2856 (2021)