Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
SLC29A2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Solute carrier family 29 member 2, Equilibrative nucleoside transporter 2, ENT2, DER12, HNP36
SLC29A2 antibody can be used for detection of SLC29A2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SLC29A2 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2). SLC29A2 is a transmembrane glycoprotein that mediates the cellular uptake of nucleosides from the surrounding medium (3). As a nucleoside transporter, SLC29A2 plays an important role in the uptake of nucleoside-based anti-cancer drugs; polymorphisms of point mutations in the gene encoding this protein may affect the efficacy of these drugs (4).
- Williams JB and Lanahan AA. A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. Biochim. Biophys. Res. Commun. 1995; 213:325-33.
- Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.
- Mangravite LM, Xiao G, and Giacomini KM. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am. J. Physiol. Renal Physiol. 284:F902-10.
- Owen RP, Lagpacan LL, Taylor TR, et al. Functional characterization and haplotype analysis of polymorphisms in the human equilabrative nucleoside transporter, ENT2. Drug Metab. Dispos. 2006; 34:12-5.
SLC29A2 antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Rat: (100%)
SLC29A2 antibody was raised against a 19 amino acid peptide near the center of human SLC29A2.
The immunogen is located within amino acids 250 - 300 of SLC29A2.
3177
solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC29A2
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 50 kDa
Observed: 50 kDa
NP_001523
38708299
SLC29A2 antibody is affinity chromatography purified via peptide column.
Cancer,Homeostasis
SLC29A2 antibody is human specific. SLC29A2 antibody is predicted to not cross-react with other SLC29 proteins.
Q14542
Optimal dilutions for each application to be determined by the researcher.