ProSci

IGF-BP1 Recombinant Protein

Product Code:
 
PSI-40-322
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized IGF-BP1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IGF-BP1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
 

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CodeSizePrice
PSI-40-322-0.005mg0.005mg£300.00
Quantity:
PSI-40-322-0.025mg0.025mg£428.00
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
AFBP, IBP1, PP12, IGF-BP25, hIGFBP-1, Insulin-like growth factor-binding protein 1, Placental protein 12, IBP-1
Background:
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).
Biological Activity:
The ED50 was Biological activity was determined by its ability to inhibit IGF - I induced proliferation of MCF - 7 is ≤ 0.5 μg/mL in the presence of 6 ng/mL of human IGF - I.
NCBI Gene ID #:
3484
NCBI Official Name:
insulin-like growth factor binding protein 1
NCBI Official Symbol:
IGFBP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000587.1
Protein GI Number:
4504615
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P08833

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