ProSci

Soluble TRAIL Receptor-1 Recombinant Protein

Product Code:
 
PSI-40-309
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Soluble TRAIL Receptor-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble TRAIL Receptor-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at
 

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CodeSizePrice
PSI-40-309-0.01mg0.01mg£300.00
Quantity:
PSI-40-309-0.05mg0.05mg£428.00
Quantity:
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Further Information

Additional Names:
DR4, APO2, CD261, TRAILR1, TRAILR-1, DR4, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TRAIL receptor 1
Background:
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Biological Activity:
Biological activity was determined by its inhibitory effect of IL - 8 production in human PBMC by human sTRAIL/Apo2L. 95% inhibition (100 ng/mL of s TRAIL/Apo2L) was reached using a concentration of 100 ng/mL of sTRAIL Receptor - 1.
NCBI Gene ID #:
8797
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 10a
NCBI Official Symbol:
TNFRSF10A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003835.3
Protein GI Number:
259906438
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O00220

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