ProSci

CALR Recombinant Protein

Product Code:
 
PSI-XW-RP3028
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Mass Spectrometry
  • Western Blot (WB)
Storage:
 
Store in working aliquots at -70°C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
 

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PSI-XW-RP3028-0.1mg0.1mg£914.00
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Further Information

Additional Names:
RO, CRT, SSA, cC1qR, HEL-S-99n, CRTC, Calreticulin, CRP55, ERp60
Application Note:
This recombinant protein can be used for WB, ELISA, MS.
Background:
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
Background References:
  • Horibe,T., Matsui,H., Tanaka,M., Nagai,H., Yamaguchi,Y., Kato,K. and Kikuchi,M. Gentamicin binds to the lectin site of calreticulin and inhibits its chaperone activity Biochem. Biophys. Res. Commun. 323 (1), 281-287 (2004)
Buffer:
10 mM Tris, pH 8.0, 0.002% NaN3, 3mM NaCl, 2.5mM
NCBI Gene ID #:
811
NCBI Official Name:
calreticulin
NCBI Official Symbol:
CALR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
46 kDa (Calculated)
Protein Accession #:
NP_004334
Protein GI Number:
4757900
Purity:
~90%
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P27797

Documents