ProSci

Osteopontin Recombinant Protein

Product Code:
 
PSI-40-122
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Osteopontin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Osteopontin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pr
 

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CodeSizePrice
PSI-40-122-0.01mg0.01mg£300.00
Quantity:
PSI-40-122-0.05mg0.05mg£428.00
Quantity:
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Further Information

Additional Names:
OPN, BNSP, BSPI, ETA-1, OPN, PSEC0156, Osteopontin, Bone sialoprotein 1, SPP-1
Background:
Osteopontin is a secreted glycoprotein that functions as a ligand to alphavbeta3 integrin and possibly other receptors. It binds tightly to hydroxyapatite and can act as a structural component of the extracellular mineralized matrix. Osteopontin is initially secreted as a 298 amino acid protein, which is subject to multiple post-translational modifications including glycosylation, phosphorylation, and specific proteolytic cleavages into various smaller molecular weight fragments. Osteopontin is expressed in a wide range of cells and tissues including osteoblasts, various tumor cell lines, extraosseous cells in the inner ear, brain, kidney, deciduum, placenta and odontoblasts. In addition to its involvement in mineralized matrix formation, Osteopontin can also function as a cytokine that stimulates the release of IFNγ and IL-12, while inhibiting the production of IL-10. Recombinant human Osteopontin is a 298 amino acid protein, which, due to glycosylation, migrates at an apparent molecular weight of 60.0-65.0 kDa by SDS-PAGE analysis under reducing conditions.
Biological Activity:
Biological activity was determined by its ability to enhance cell adhesion of murine B16-F1 cells.
NCBI Gene ID #:
6696
NCBI Official Name:
secreted phosphoprotein 1
NCBI Official Symbol:
SPP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000573.1
Protein GI Number:
4759166
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P10451

Documents