ProSci

OX40 Ligand Recombinant Protein

Product Code:
 
PSI-40-317
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized OX40 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted OX40 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pr
 

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CodeSizePrice
PSI-40-317-0.002mg0.002mg£300.00
Quantity:
PSI-40-317-0.01mg0.01mg£428.00
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Further Information

Additional Names:
GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40L
Background:
OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between "friend vs. foe? during activation; a mechanism typically termed immuno-tolerance. Recombinant OX40L is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 - 25.0 kDa on SDS-PAGE.
Biological Activity:
Biological activity was determined by its ability to stimulate IL - 8 production by human PBMC using a concentration range of 30 - 100 ng/mL. Note: Results may vary with PBMC donors.
NCBI Gene ID #:
7292
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 4
NCBI Official Symbol:
TNFSF4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003317.1
Protein GI Number:
4507603
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Source:
High-5 Insect cells
Swissprot #:
P23510

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