ProSci

PDGF-AA Recombinant Protein

Product Code:
 
PSI-40-457
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
The lyophilized PDGF-AA recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted PDGF-AA is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
 

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CodeSizePrice
PSI-40-457-0.002mg0.002mg£300.00
Quantity:
PSI-40-457-0.01mg0.01mg£428.00
Quantity:
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Further Information

Additional Names:
Platelet-derived growth factor subunit A, PDGF-1, PDGF subunit A
Background:
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids).
Biological Activity:
Biological activity was determined by the dose - dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 8 - 10 ng/mL.
NCBI Gene ID #:
18590
NCBI Official Name:
platelet derived growth factor, alpha
NCBI Official Symbol:
Pdgfa
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_032834.1
Protein GI Number:
6715566
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P20033

Documents