ProSci

Persephin Recombinant Protein

Product Code:
 
PSI-40-506
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Storage:
 
The lyophilized Persephin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Persephin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protei
 

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CodeSizePrice
PSI-40-506-0.005mg0.005mg£300.00
Quantity:
PSI-40-506-0.02mg0.02mg£428.00
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Further Information

Additional Names:
PSP, Persephin, PSP
Background:
Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration
Biological Activity:
The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/mL, corresponding to a specific activity of > 1 x 107 units/mg.
NCBI Gene ID #:
19197
NCBI Official Name:
persephin
NCBI Official Symbol:
Pspn
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Protein Accession #:
NP_032980.2
Protein GI Number:
247269886
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O70300

Documents