ProSci

CD161 Antibody [HP-3G10] (Violet-450)

Product Code:
 
PSI-76-833
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
HP-3G10
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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PSI-76-833-25tests25tests£344.00
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Further Information

Additional Names:
NKR, CD161, CLEC5B, NKR-P1, NKRP1A, NKR-P1A, hNKR-P1A, KLRB1
Background:
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, gammadelta TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role. BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Background References:
  • Mrquez, C., Trigueros, C., Franco, J. M., Ramiro, A. R., Carrasco, Y. R., Lpez-Botet, M., Toribio, M. L. (1998). Identification of a common developmental pathway for thymic natural killer cells and dendritic cells.Blood,91(8), 2760-2771.
  • Cosmi, L., De Palma, R., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., ... Annunziato, F. (2008). Human interleukin 17producing cells originate from a CD161+ CD4+ T cell precursor.The Journal of experimental medicine,205(8), 1903-1916.
  • Exley, M., Porcelli, S., Furman, M., Garcia, J., Balk, S. (1998). CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant Valpha 24Jalpha Q T cell receptor alpha chains.The Journal of experimental medicine,188(5), 867-876.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
Violet-450
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
3820
NCBI Official Name:
killer cell lectin-like receptor subfamily B, member 1
NCBI Official Symbol:
KLRB1
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity,Immunology
SPECIFICITY:
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A.
Swissprot #:
Q12918
User NOte:
Optimal dilutions for each application to be determined by the researcher.