ProSci

EPB41 (phospho Tyr660/418) Antibody

Product Code:
 
PSI-79-909
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from HepG2 cells treated with PMA using EPB41 (Phospho-Tyr660/418) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from HepG2 cells treated with PMA using EPB41 (Phospho-Tyr660/418) Antibody. The lane on the right is treated with the antigen-specific peptide.

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PSI-79-909-0.1mg0.1mg£488.00
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Further Information

Additional Names:
E41P, EPB4.1, band 4.1, P4.1
Application Note:
Western Blot: 1:500~1:1000
Background:
Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene.
Background References:
  • Conboy J.G., Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986).
  • Tang T.K., Adv. Exp. Med. Biol. 241:81-95(1988).
  • Tang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EPB41 (phospho Tyr660/418) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y (p)-I-R)derived from Human EPB41.
Modifications:
Phospho-Specific
NCBI Gene ID #:
2035
NCBI Official Name:
erythrocyte membrane protein band 4.1
NCBI Official Symbol:
EPB41
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
NP_001159477.1
Protein GI Number:
260436831
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of EPB41 only when phosphorylated at tyrosine 660/418.
Swissprot #:
P11171