ProSci

ATF-4 (phospho Ser219) Antibody

Product Code:
 
PSI-79-940
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from COLO cells using ATF-4 (Phospho-Ser219) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Western blot analysis of extracts from COLO cells using ATF-4 (Phospho-Ser219) Antibody. The lane on the right is treated with the antigen-specific peptide.

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PSI-79-940-0.1mg0.1mg£488.00
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Further Information

Additional Names:
ATF4, CREB-2, DNA-binding protein TAXREB67, TXREB
Application Note:
Western Blot: 1:500~1:1000
Background:
ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
Background References:
  • Sato T., Shimotohno K. J. Virol. 65:1420-1426(1991)
  • Leiden J.M. Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992)
  • Bridgeman A.M. Wright H. Nature 402:489-495(1999)
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ATF-4 (phospho Ser219) antibody was raised against a peptide sequence around phosphorylation site of Serine 219 (N-D-S (p)-G-T) derived from Human ATF-4.
Modifications:
Phospho-Specific
NCBI Gene ID #:
468
NCBI Official Name:
activating transcription factor 4
NCBI Official Symbol:
ATF4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
NP_001666.2
Protein GI Number:
33469976
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The Antibody detects endogenous levels of ATF-4 only when phosphorylated at Serine 219.
Swissprot #:
P18848