ProSci

FRS2 (phospho Tyr436) Antibody

Product Code:
 
PSI-79-880
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20°C for up to one year.
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Western blot analysis of extracts from HuvEc cells (Lane 2) and JK cells (Lane 3), using FRS2 (Phospho-Tyr436) Antibody. The lane on the left is treated with antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human brain tissue using FRS2 (Phospho-Tyr436) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Western blot analysis of extracts from HuvEc cells (Lane 2) and JK cells (Lane 3), using FRS2 (Phospho-Tyr436) Antibody. The lane on the left is treated with antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human brain tissue using FRS2 (Phospho-Tyr436) antibody (left) or the same antibody preincubated with blocking peptide (right).

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PSI-79-880-0.1mg0.1mg£488.00
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Further Information

Additional Names:
SNT-1, SNT2, FGFR signalling adaptor
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.
Background References:
  • Xu H., J. Biol. Chem. 273:17987-17990(1998).
  • Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
  • Dhalluin C., Mol. Cell 6:921-929(2000).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FRS2 (phospho Tyr436) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 436 (L-N-Y (p)-I-Q) derived from Human FRS2 .
Modifications:
Phospho-Specific
NCBI Gene ID #:
10818
NCBI Official Name:
fibroblast growth factor receptor substrate 2
NCBI Official Symbol:
FRS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65 kDa
Protein Accession #:
NP_001036020.1
Protein GI Number:
110347408
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of FRS2 only when phosphorylated at tyrosine 436.
Swissprot #:
Q8WU20