ACK1 (phospho Tyr284) Antibody
Antibody Clonality:
Polyclonal
Applications:- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20°C for up to one year.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
ACK1, Activated p21cdc42Hs kinase, EC 2.7.10.2, kinase ACK1
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes.
- Manser E., Nature 363:364-367(1993).
- Ota T., Nat. Genet. 36:40-45(2004).
- Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
ACK1 (phospho Tyr284) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y (p)-V-M) derived from Human ACK1.
Phospho-Specific
10188
tyrosine kinase, non-receptor, 2
TNK2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
120 kDa
NP_005772.3
229462980
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Phospho-Specific
The antibody detects endogenous levels of ACK1 only when phosphorylated at tyrosine 284.
Q07912