ProSci

CD335 Antibody [29A1.4] (PE)

Product Code:
 
PSI-76-982
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2b, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
29A1.4
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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CodeSizePrice
PSI-76-982-0.025mg0.025mg£373.00
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Further Information

Additional Names:
Ly94, NKp46, Ncr1
Background:
The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule. It is expressed in only NK and a rare subset of NK-like T cells, not including the CD1d-restricted NKT division. CD335 is active during NK lysis of pathogen-infected and tumor cells.The 29A1.4 in vitro activates NK cells, but does not deplete NK cells in vivo.
Background References:
  • Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., ... Sakaguchi, S. (2005). Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+ CD25+ CD4+ regulatory T cells.The Journal of experimental medicine,202(7), 885-891.
  • Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S. (2002). Stimulation of CD25+ CD4+ regulatory T cells through GITR breaks immunological self-tolerance.Nature immunology,3(2), 135-142.
  • Tone, M., Tone, Y., Adams, E., Yates, S. F., Frewin, M. R., Cobbold, S. P., Waldmann, H. (2003). Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.Proceedings of the National Academy of Sciences,100(25), 15059-15064.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
17086
NCBI Official Name:
natural cytotoxicity triggering receptor 1
NCBI Official Symbol:
Ncr1
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity
SPECIFICITY:
The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule.
Swissprot #:
Q8C567
User NOte:
Optimal dilutions for each application to be determined by the researcher.