ProSci

CD132 Recombinant Protein

Product Code:
 
PSI-96-466
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-466-0.1mg0.1mg£597.00
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Further Information

Additional Names:
IL2RG, CD132, CIDX, IMD4, P64, SCIDX, SCIDX1, gammaC
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).
Background References:
  • Kondo M., et al., 1993, Science 262:1874-1877.
  • Russell S.M., et al., 1993, Science 262:1880-1883.
  • Noguchi M., et al., 1993, Science 262:1877-1880.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
3561
NCBI Official Name:
interleukin 2 receptor, gamma
NCBI Official Symbol:
IL2RG
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
53.5 kDa
Protein Accession #:
AAH14972
Purity:
>98% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P31785

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