ProSci

IL18 BP Recombinant Protein

Product Code:
 
PSI-96-469
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-469-0.2mg0.2mg£657.00
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Further Information

Additional Names:
IL18BP, IL18BPa, Tadekinig-alfa
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
Background References:
  • Novick D., et al., 1999, Immunity 10:127-136.
  • Aizawa Y., et al., 1999, FEBS Lett. 445:338-342.
  • Halim A., et al., 2011, Mol. Cell. Proteomics 0:0-0.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
10068
NCBI Official Name:
interleukin 18 binding protein
NCBI Official Symbol:
IL18BP
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
44.3 kDa
Protein Accession #:
NP_001138529
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
O95998

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