ProSci

Osteoactivin Recombinant Protein

Product Code:
 
PSI-96-368
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-368-0.1mg0.1mg£626.00
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Further Information

Additional Names:
GPNMB, HGFIN, NMB, Osteoactivin
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Background References:
  • Weterman MA., et al., 1995, International Journal of Cancer 60 : 73?81.
  • Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334?51.
  • Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26?37.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
10457
NCBI Official Name:
glycoprotein (transmembrane) nmb
NCBI Official Symbol:
GPNMB
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
52.9 kDa
Protein Accession #:
AAH32783
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q14956

Documents