ProSci

Lumican Recombinant Protein

Product Code:
 
PSI-96-526
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-526-0.1mg0.1mg£626.00
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Further Information

Additional Names:
LUM, Lumican, LDC, SLRR2D, KSPG lumican
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Lumican (LUM) is also known as Keratan sulfate proteoglycan lumican, KSPG lumican,LDC and SLRR2D, which belongs to the small leucine-rich proteoglycan (SLRP) family and SLRP class II subfamily. LUM /Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage LUM /Lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan. LUM participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of LUM has been correlated to the growth and metastasis of various malignancies.
Background References:
  • Onnerfjord P., et al., 2004, J. Biol. Chem. 279:26-33.
  • Grover J., et al., 1995, J. Biol. Chem. 270:21942-21949.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
176
NCBI Official Name:
aggrecan
NCBI Official Symbol:
ACAN
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
37.5 kDa
Protein Accession #:
NP_002336
Purity:
>95% as determined by reduced SDS-PAGE.

Less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P51884

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