ProSci

MMP1 Recombinant Protein

Product Code:
 
PSI-96-537
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-537-0.05mg0.05mg£686.00
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Further Information

Additional Names:
MMP1, CLG, CLGN
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metalloproteinase-1 (MMP-1) is also known as interstitial collagenase and fibroblast collagenase. MMP?1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP-1 breaks down the interstitial collagens, types I, II, and III. MMP?1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, myelin basic protein, L?Selectin, pro?TNF, IL?1β, IGF?BP3, IGF?BP5, pro MMP?2 and pro MMP?9.
Background References:
  • Hirose Y, et al., 2008, Am. J. Hum. Genet. 82 (5): 1122?9.
  • Brinckerhoff CE., et al., 1987, J. Clin. Invest. 79 (2): 542?6.
  • Huang SF,et al., 2008, Eur. J. Oral Sci. 116 (4): 319?23.
Biological Activity:
Measured by its ability to cleave a fluorogenic peptide substrate Mca - KPLGL - Dpa - AR - NH2. The?specific?activity?is?>?200?pmol/min/μg.
Buffer:
20 mM MES, 150 mM NaCl, 10 mM CaCl2, pH6.0 with 0.05% Brij-35
Fusion Tag:
His Tag
NCBI Gene ID #:
4312
NCBI Official Name:
matrix metallopeptidase 1 (interstitial collagenase)
NCBI Official Symbol:
MMP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
52.7 kDa
Protein Accession #:
NP_002412.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P03956

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