ProSci

MMP9 Recombinant Protein

Product Code:
 
PSI-96-539
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-539-0.05mg0.05mg£765.00
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Further Information

Additional Names:
MMP9, CLG4B, GELB, MANDP2, Gelatinase B
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Matrix metallopeptidase 9 (MMP-9) is also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. . Structurally, MMP9 maybe be divided into five distinct domains: a prodomain which is cleaved upon activation, a gelatinbinding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a prolinerich linker region, and a carboxyl terminal hemopexinlike domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target.
Background References:
  • Hirose Y, et al., 2008, Am. J. Hum. Genet. 82 (5): 1122?9.
  • Mira, E. et al., 2004, J. Cell. Sci. 117:1847-1857.
Biological Activity:
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2. The specific activity is >1200 pmol/min/μg.
Buffer:
50 mM Tris, 10 mM CaCl2, 150 mM NaCl, pH7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
4318
NCBI Official Name:
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
NCBI Official Symbol:
MMP9
NCBI Organism:
homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
50.8 kDa
Protein Accession #:
AAH06093
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P14780

Documents