ProSci

IGF II Recombinant Protein

Product Code:
 
PSI-96-412
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
PSI-96-412-0.1mg0.1mg£524.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Additional Names:
IGF2, C11orf43, FLJ22066, FLJ44734, IGF-II, PP9974
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Insulin-like growth factor 2 (IGF-2) is also known as Somatomedin-A, IGF-II, PP9974, and is one of three protein hormones that share structural similarity to insulin. IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist; that is, to prevent IGF2 responses. The major role of IGF2 is as a growth promoting hormone during gestation. In the process of Folliculogenesis, IGF2 is created by Theca cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on Granulosa cells in the ovary. IGF2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside Follicle Stimulating Hormone (FSH). After ovulation has occurred, IGF-2 promotes progesterone secretion during the luteal phase of the menstrual cycle together with Luteinizing Hormone (LH). Thus, IGF2 acts as a Co-hormone together with both FSH and LH. IGF-2 may play a key role in memory and could potentially be used to treat Alzheimer's Disease. It is sometimes produced in excess in islet cell tumours, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. has been shown to interact with IGFBP3 and Transferrin.
Background References:
  • MacRae, Fiona , 2011, Daily Mail (London).
  • Balduyck B,et al., 2006, J Thorac Oncol 1 (6): 588?90.
  • Storch, S, et al., 2001, FEBS Lett. (Netherlands) 509 (3): 395?8.
  • Buckway, C K, et al., 2001, J. Clin. Endocrinol. Metab. (United States) 86 (10): 4943?50.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
N-Fc Tag
NCBI Gene ID #:
3481
NCBI Official Name:
insulin-like growth factor 2 (somatomedin A)
NCBI Official Symbol:
IGF2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
35 kDa
Protein Accession #:
P01344-1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P01344

Documents