ProSci

BMP 2 Recombinant Protein

Product Code:
 
PSI-96-065
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-065-0.02mg0.02mg£469.00
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Further Information

Additional Names:
BMP2, BMP2A
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Human bone morphogenetic protein 2 (BMP2) is also known as human BMP-2, BMP-2, BMP2, BMP 2, h-BMP-2, rh-BMP-2, recombinant human BMP-2, recombinant BMP-2, BMP, is a member of the BMP subgroup belonging to the TGF-b superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. As implied by its name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function.
Background References:
  • Lai, T.H. et al., (2008) Prostate. 68: 1341-1353.
  • Kruithof BP,et al. Genesis. 2011 Apr 18. doi: 10.1002/dvg.20757.
  • Grgurevic L, et al. Biochem Biophys Res Commun. 2011 Apr 29;408(1):25-31.
Biological Activity:
Corresponding to a specific activity of 20000 IU/mg. The ED50 as determined by the cytolysis of MC3T3-E1 cells is <50 ng/mL.
Buffer:
0.1M acetic acid, pH2.0
Fusion Tag:
Tag free
NCBI Gene ID #:
650
NCBI Official Name:
bone morphogenetic protein 2
NCBI Official Symbol:
BMP2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
13 kDa
Protein Accession #:
NP_001191
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P12643

Documents