Chemodex

Berberine chloride

Product Code:
 
CDX-B0212
Product Group:
 
Inhibitors and Activators
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
+4°C
1 / 1
Chemical Structure
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Chemical Structure

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CDX-B0212-G01010 g£65.00
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CDX-B0212-G02525 g£121.00
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CDX-B0212-G05050 g£194.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Natural Yellow 18; Berberinium chloride; BBR; Umbellatine; Majarine; Thalsine
Appearance:
Yellow to orange powder.
CAS:
633-65-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
InChi:
InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChiKey:
VKJGBAJNNALVAV-UHFFFAOYSA-M
Long Description:
Chemical. CAS: 633-65-8. Formula: C20H17NO4 . HCl. MW: 335.3 . 36.5. Synthetic Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK. Potent, uncompetitive, reversible IDO 1 inhibitor with IC50 values of 7 µM (cell-based assay) and 9.3 µM (enzymatic assay), and Ki value 8µM.
MDL:
MFCD00011939
Molecular Formula:
C20H17NO4 . HCl
Molecular Weight:
335.3 . 36.5
Package Type:
Vial
Product Description:
Natural fluorescent dye, used in histology for staining heparin in mast cells. An isoquinoline alkaloid, which shows antibacterial, antifungal, anti-inflammatory, anti-oxidant, antidiabetic, antiviral and anticancer activity. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. Broad spectrum enzyme inhibitor, affects N-acetyltransferase, cyclooxygenase-2, and topoisomerase activities and gene/protein expression. Increases adiponectin expression, upregulates LDLR and insulin receptor. Anti-hyperglycemic, by inhibition of aldose reductase, inducing glycolysis, preventing insulin resistance through increasing insulin receptor expression and acting like incretins. Activates AMPK and ERK. Potent, uncompetitive, reversible IDO1 inhibitor with IC50 values of 7 µM (cell-based assay) and 9.3 µM (enzymatic assay), and Ki value 8µM. Inhibits BAFF production in H. pylori-induced chronic gastritis.
Purity:
>98% (TLC)
SMILES:
[Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3
Solubility Chemicals:
Soluble in DMSO or methanol. Slightly soluble in ethanol or water.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

(1) P.J. Kaboli, et al.; Eur. J. Pharmacol. 740, 584 (2014) | (2) L.M. Ortiz, et al.; Molecules 19, 12349 (2014) | (3) W.J. Ni, et al.; Eur. J. Pharmacol. 760, 103 (2015) | (4) C.J. Yu, et al.; J. Alzheimers Dis. 22, 257 (2010)