Chemodex

7beta-Hydroxycholesterol

Product Code:
 
CDX-H0116
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
+4°C
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Chemical Structure
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Chemical Structure

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CDX-H0116-M0055 mg£157.00
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CDX-H0116-M01010 mg£255.00
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CDX-H0116-M100100 mg£1,170.00
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Further Information

Alternate Names/Synonyms:
5-Cholestene-3beta,7beta-diol
Appearance:
White to white-yellow powder.
CAS:
566-27-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light and moisture.
InChi:
InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24+,25+,26+,27-/m1/s1
InChiKey:
OYXZMSRRJOYLLO-KGZHIOMZSA-N
Long Description:
Chemical. CAS: 566-27-8. Formula: C27H46O2. MW: 402.65. Synthetic Oxysterole. Cholesterol oxidation metabolite. Induces cell death/apoptosis and shows antiproliferative activity against cancer cells, involving mitochondrial perturbation, oxidative stress and lysosomal destabilization. Its membrane organizing properties may have implications in Alzheimer?s disease. Increased levels correlate with risk of cardiovascular diseases including atherosclerosis. Shown to have proinflammatory activity.
MDL:
MFCD00058406
Molecular Formula:
C27H46O2
Molecular Weight:
402.65
Package Type:
Vial
Product Description:
Oxysterole. Cholesterol oxidation metabolite. Induces cell death/apoptosis and shows antiproliferative activity against cancer cells, involving mitochondrial perturbation, oxidative stress and lysosomal destabilization. Its membrane organizing properties may have implications in Alzheimer?s disease. Increased levels correlate with risk of cardiovascular diseases including atherosclerosis. Shown to have proinflammatory activity.
Purity:
>98% (HPLC)
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
Solubility Chemicals:
Soluble in ethanol, chloroform or methanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) S. Lemaire, et al.; FEBS Lett. 440, 434 (1998) | (2) G. Lizard, et al.; Arterioscler. Thromb. Vasc. Biol. 19, 1190 (1999) | (3) J. Wang, et al.; Biochem. 43, 1010 (2004) | (4) S. Roussi, et al.; Cell Death Differ. 12, 128 (2005) | (5) K.A. Kang, et al.; Biol. Pharm. Bull. 28, 1377 (2005) | (6) S. Roussi, et al.; Apoptosis 12, 87 (2007) | (7) S. Lordan, et al.; Int. J. Toxicol. 27, 279 (2008) | (8) W. Li, et al.; Free Radic. Res. 43, 1072 (2009) | (9) L. Trevisi, et al.; J. Vasc. Res. 47, 241 (2010) | (10) C. Mascia, et al.; Free Radic. Biol. Med. 49, 2049 (2010)