AdipoGen Life Sciences

MBIMPH

Product Code:
 
AG-CR1-3907
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
-20°C
Storage:
 
+4°C (short term), -20°C (long term).
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Chemical Structure
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Chemical Structure

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AG-CR1-3907-M0011 mg£150.00
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AG-CR1-3907-M0055 mg£570.00
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Further Information

Alternate Names/Synonyms:
N-Hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide
Appearance:
Off-white solid.
CAS:
1392835-53-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep cool and dry.Protect from light.
InChi:
InChI=1S/C16H15N3O2/c1-11-17-14-4-2-3-5-15(14)19(11)10-12-6-8-13(9-7-12)16(20)18-21/h2-9,21H,10H2,1H3,(H,18,20)
InChiKey:
SGZCUGGIJNIVPP-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 1392835-53-8. Formula: C16H15N3O2. MW: 281.3. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Molecular Formula:
C16H15N3O2
Molecular Weight:
281.3
Package Type:
Vial
Product Description:
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (Prod. No. AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Purity:
>98% (HPLC)
SMILES:
CC1=NC2=C(C=CC=C2)N1CC1=CC=C(C=C1)C(=O)NO
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Bicyclic-capped histone deacetylase 6 inhibitors with improved activity in a model of axonal charcot-marie-tooth disease: S. Shen, et al.; ACS Chemical Neuroscience (submitted) (2015)