ProSci

ALSFTD Antibody

Product Code:
 
PSI-8469
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
ALSFTD antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
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Western blot analysis of ALSFTD in HeLa cell lysate with ALSFTD antibody at 1 μg/ml.
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Immunocytochemistry of ALSFTD in A-20 cells with ALSFTD antibody at 10 μg/ml.
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Western blot analysis of ALSFTD in HeLa cell lysate with ALSFTD antibody at 1 μg/ml.
Immunocytochemistry of ALSFTD in A-20 cells with ALSFTD antibody at 10 μg/ml.

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CodeSizePrice
PSI-8469-0.02mg0.02mg£150.00
Quantity:
PSI-8469-0.1mg0.1mg£449.00
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Further Information

Additional Names:
Amyotrophic lateral sclerosis with frontotemporal dementia, chromosome 9 open reading frame 72, C9orf72
Application Note:
ALSFTD antibody can be used for the detection of ALSFTD by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry at 10 μg/ml.

Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Background:
ALSFTD (C9orf72) is considered to play a role in gender determination (1). Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG (2). Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster (3,4).
Background References:
  • Takada LT and Sha SJ. Neuropsychiatric features of C9orf72-associated behavioral variant frontotemporal dementia and frontotemporal dementia with motor neuron disease. Alzheimers Res. Ther. 2012; 4:38.
  • Coon EA, Whitwell JL, Parisi JE, et al. Right temporal variant frontotemporal dementia with motor neuron disease. J. Clin. Neurosci. 2012; 19:85-91.
  • Snowden JS, Rollinson S, Thompson JC, et al. Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. Brain 2012; 135:693-708.
  • Wen X, Tan W, Westergard T, et al. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron 2014; 84:1213-25.
Buffer:
ALSFTD Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ALSFTD antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ALSFTD.

The immunogen is located within amino acids 400 - 450 of ALSFTD.
NCBI Gene ID #:
203228
NCBI Official Name:
chromosome 9 open reading frame 72
NCBI Official Symbol:
ALSFTD
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 53 kDa

Observed: 52 kDa
Protein Accession #:
NP_060795
Protein GI Number:
37039612
Purification:
ALSFTD Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
SPECIFICITY:
ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.
Swissprot #:
Q96LT7
User NOte:
Optimal dilutions for each application to be determined by the researcher.