ProSci

CD40 Antibody [FGK45] (preservative free)

Product Code:
 
PSI-36-148
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
FGK45
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Functional Study
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C.
 

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PSI-36-148-100ug100ug£488.00
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Further Information

Additional Names:
Tumor Necrosis Factor Receptor Superfamily Member 5; CD40L Receptor
Application Note:
Functional Application: Activates B and NK cells in vivo and in vitro.
Background:
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
Buffer:
Liquid. In PBS. Preservative free formulation.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Recombinant mouse CD40 fusion protein.
NCBI Gene ID #:
21939
NCBI Official Name:
CD40 antigen
NCBI Official Symbol:
Cd40
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
172046819
Protein GI Number:
P27512
Purification:
>95% (SDS-PAGE)
Research Area:
Cancer,Immunology,Innate Immunity,Functional Assays
SPECIFICITY:
Recognizes mouse CD40.
Swissprot #:
P27512
User NOte:
Optimal dilutions for each application to be determined by the researcher.