ProSci

Betatrophin Recombinant Protein

Product Code:
 
PSI-90-325
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Stable for at least 6 months after receipt when stored at -20˚C.
 

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PSI-90-325-10ug10ug£657.00
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Further Information

Additional Names:
Angiopoietin-like Protein 8, ANGPTL8, Lipasin, Refeeding-induced Fat and Liver Protein, RIFL
Application Note:
This recombinant proteins is for research use only.
Background:
Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
Buffer:
Contains PBS + 0.02% CHAPS. Reconstitute with 100 μl sterile water.
Concentration:
0.1mg/ml after reconstitution.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
55908
NCBI Official Name:
chromosome 19 open reading frame 80
NCBI Official Symbol:
C19orf80
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
Q6UXH0
Protein GI Number:
291219911
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8N5Z0

Documents