ProSci

IL-35 Recombinant Protein

Product Code:
 
PSI-90-535
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-535-25ug25ug£669.00
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Further Information

Additional Names:
Interleukin-35
Application Note:
This recombinant proteins is for research use only.
Background:
Interleukin-35 (IL-35) is a novel IL-12 family cytokine produced by regulatory T cells (Treg) but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric protein composed of EBI3 (Epstein-Barr-Virus-induced gene 3) and IL-12a (p35). EBI3 is a downstream target of Foxp3, a transcription factor required for Treg-cell development and function, and thus Treg-cell restriction of IL35 occurs. Regulatory T cells are essential for maintaining self tolerance and preventing autoimmunity, and IL-35 is identified as a molecule that mediates the immune suppression function of Treg-cell. As an inhibitory cytokine, IL-35 induces proliferation of Treg-cell populations but suppresses Th17 cell development. Studies in mice show the absence of either IL-35 chain from Treg-cell reduces the cells' ability to suppress inflammation using an experimental model for inflammatory bowel disease. IL-35 is suggested as a potential target of immunotherapy.
Biological Activity:
Bioactivity was measured in a cell proliferation assay using anti-CD3 activated human peripheral mononuclear cells.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
10148
NCBI Official Name:
Epstein-Barr virus induced 3
NCBI Official Symbol:
EBI3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_005746/NP_000873
Protein GI Number:
14577917
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
Q4QNY4

Documents