ProSci

HMGB1 Recombinant Protein

Product Code:
 
PSI-90-457
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
 

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PSI-90-457-25ug25ug£560.00
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Further Information

Additional Names:
High Mobility Group Protein B1
Application Note:
This recombinant proteins is for research use only.
Background:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
Buffer:
Lyophilized from a concentrated sterile solution containing 50mM Tris-Hcl buffer (pH 8.0) and 100mM NaCl. Reconstituted in sterile H2O not less than 100 μg/ml, which can then be further diluted in other aqueous solutions.
Fusion Tag:
His Tag
NCBI Gene ID #:
3146
NCBI Official Name:
high mobility group box 1
NCBI Official Symbol:
HMGB1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_002119
Protein GI Number:
4504425
Purity:
>90% (SDS-PAGE).

Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P40933

Documents